Obesity
Obesity is quickly becoming an
epidemic in the United States as well as in other places in the developed
world. Obesity increases the risk of type 2 diabetes and is therefore a
major reason for the recent increased incidence of diabetes. Dr. Surwit
has been a pioneer in studying the interaction of diet and genetic factors
in the development and treatment of obesity and type 2 diabetes. His work
has shown that fat interacts with genetic predispositions to cause obesity
in animals, and that very low fat diets are effective in treating obesity
and type 2 diabetes. Some of Dr. Surwit’s most important publications in
this area are listed below.
- Surwit, R.S., Kuhn, C.M., Cochrane, C., McCubbin,
J.A. and Feinglos, M.N. Diet-induced type II diabetes in C57BL/6J mice.
Diabetes, 1988, 37,
1163-1167.
- Surwit, R.S., Feinglos, M.N, Rodin, J, Sutherland,
A. Petro, A.E., Opara, E.C, Kuhn, C, Rebuffe-Scrive, M. Differential
effects of fat and sucrose on the development of obesity and diabetes in
C57BL/6J and A/J mice. Metablism, 1995, 44, 645-651.
- Collins, S., Kuhn, C.M., Petro, A.E., Swick, A.G., Chruny, B.A., and
Surwit, R.S. Role of Leptin in fat regulation.
Nature, 1996, 380,
667.
- Brownlow, B.S., Petro, A., Feinglos, M.N. and Surwit,
R.S. The role of motor activity in diet-induced obesity in
C57BL/6J mice. Physiology and Behavior, 1996, 60, 37-41.
- Surwit, R.S., Feinglos, M.N., McCaskill, C.C.,
Clay, S.L, Babyak, M.A., Brownlow, B.S., Plaisted, C.D., Lin, Pao-Hwa.
Metabolic and behavioral effects of a high sucrose diet in weight loss.
American Journal of Clinical Nutrition, 1997, 65, 908-915.
- Fleury, C., Neverova, M., Collins, S., Raimbault, S., Champign, O.,
Levi-Meyrueis, C., Bouillaud, F., Seldin, M.F., Surwit,
R.S., Ricquier, D., and Warden, C.H. Uncoupling protein-2: A
novel candidate thermogenic protein linked to obesity and insulin
resistance. Nature Genetics, 1997, 15, 269-272
- Surwit, R.S., Petro, A.E., Parekh, P., and Collins,
S. Low plasma leptin in response to dietary fat in diabetes- and
obesity-prone mice. Diabetes, 1997, 46, 1516-1520.
- Surwit, R.S., Wang, S., Petro, A.E., Sanchis, D.,
Raimbault, S., Ricquier, D., and Collins, S. Diet-induced changes in
uncoupling proteins in obesity-prone and obesity-resistant strains of
mice. Proc. Nation. Acad. Sci., 1998, 95, 4061-4065.
- Parekh, P.I., Petro, A.E., Tiller, J.M., Feinglos, M.N., and
Surwit, R.S. Reversal of diet-induced obesity and
diabetes in C57BL/6J mice. Metabolism, 1998, 47, 1089-1096.
- Surwit, R.S., Edwards, C.L., Murthy, S., and Petro,
A.E. Transient effects of long-term leptin supplementation in the
prevention of diet-induced obesity in mice. Diabetes,
2000, 49, 1203-1208.
- Surwit, R.S., Dixon, T.M., Petro, A.E., Daniel,
K.W. and Collins, S. Diazoxide restores b3-Adrenergic Receptor Function
in Diet-Induced Obesity and Diabetes. Endocrinology, 2000, 141,
3630-3637.
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